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FreeSurfer performs the whole cortical reconstruction process and generates it their unique FreeSurfer file format using the command recon-all. Outlined below are instructions on how to pre-process structural T1 data using recon-all automatically (which could encounter problems with segmentations and cortical tracing), and manually (which allows you to check and correct any errors).

AFTER conducting recon-all:

  1. If you are interested in running longitudinal analysis, you will also need to pre-process the data using the longitudinal pre-processing pipeline.

  2. If you are interested in running analysis segmenting hippocampal subfields or amygdala, you should run further processing and analysis as outlined here.

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Running whole pre-processing pipeline automatically

You can automatically run the whole process (without manual editing/manual checks):

  1. with a niftii file

Code Block
recon-all -i FTD####.nii -subjid subject_1 -all
  1. with a folder of DICOM files

Code Block
recon-all -i /scratch/project/FTD#### -subjid subject_1 -all

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Pre-processing with manual corrections

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Code Block
recon-all -subjid subject_1 -qcache

Running whole pre-processing pipeline automatically

You can automatically run the whole process (without manual editing/manual checks):

  1. with a niftii file

Code Block
recon-all -i FTD####.nii -subjid subject_1 -all

2. with a folder of DICOM files

Code Block
recon-all -i /scratch/project/FTD#### -subjid subject_1 -all

...